a. Efficacy: Quality of life, complete wound closure, time to complete wound healing (skin closure without drainage or dressing requirements), improvements in wound care (infection, impact on the incidence of other problems, such as sepsis, edema, or amputation), satisfaction with treatment, duration of treatment, and survival, Intermediate outcomes: time to 50% reduction of wound volume, percent change in wound volume, and improved wound condition<br>b. Safety: Pain, bleeding, infection/ bacterial load, other complications, mortality (p. 50ff)

chronic and acute Wounds (Pressure ulcers, Diabetic/neuropathic ulcers, Venous insufficiency ulcers, Traumatic wounds, Post-operative and dehisced surgical wounds, Explored fistulae, Skin flaps and grafts, subacute, dehisced wounds, partial-thickness burns)

L89, E14.5, I87.2, T79.3, T81.4,